Polyketide stereocontrol: a study in chemical biology.
Fiche publication
Date publication
janvier 2017
Journal
Beilstein journal of organic chemistry
Lien Pubmed
Résumé
The biosynthesis of reduced polyketides in bacteria by modular polyketide synthases (PKSs) proceeds with exquisite stereocontrol. As the stereochemistry is intimately linked to the strong bioactivity of these molecules, the origins of stereochemical control are of significant interest in attempts to create derivatives of these compounds by genetic engineering. In this review, we discuss the current state of knowledge regarding this key aspect of the biosynthetic pathways. Given that much of this information has been obtained using chemical biology tools, work in this area serves as a showcase for the power of this approach to provide answers to fundamental biological questions.
Mots clés
chemical biology, polyketide synthases, reduced polyketides, stereocontrol
Référence
Beilstein J Org Chem. 2017 ;13:348-371