Targeting VEGF-A with a vaccine decreases inflammation and joint destruction in experimental arthritis.
Fiche publication
Date publication
janvier 2016
Journal
Angiogenesis
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MULLER Sylviane
Tous les auteurs :
Semerano L, Duvallet E, Belmellat N, Marival N, Schall N, Monteil M, Grouard-Vogel G, Bernier E, Lecouvey M, Hlawaty H, Muller S, Boissier MC, Assier E
Lien Pubmed
Résumé
Inflammation and angiogenesis are two tightly linked processes in arthritis, and therapeutic targeting of pro-angiogenic factors may contribute to control joint inflammation and synovitis progression. In this work, we explored whether vaccination against vascular endothelial growth factor (VEGF) ameliorates collagen-induced arthritis (CIA).
Mots clés
Amino Acid Sequence, Animals, Antibody Formation, immunology, Arthritis, Experimental, immunology, Human Umbilical Vein Endothelial Cells, Humans, Immunity, Humoral, immunology, Immunization, Inflammation, pathology, Joints, pathology, Male, Mice, Molecular Sequence Data, Molecular Targeted Therapy, Peptides, chemistry, Synovial Membrane, blood supply, Vaccines, immunology, Vascular Endothelial Growth Factor A, chemistry
Référence
Angiogenesis. 2016 Jan;19(1):39-52