Genetic and transcriptomic analyses provide new insights on the early antiviral response to VHSV in resistant and susceptible rainbow trout.
Fiche publication
Date publication
juin 2018
Journal
BMC genomics
Auteurs
Membres identifiés du Cancéropôle Est :
Dr VERRIER Eloi
Tous les auteurs :
Verrier ER, Genet C, Laloë D, Jaffrezic F, Rau A, Esquerre D, Dechamp N, Ciobotaru C, Hervet C, Krieg F, Jouneau L, Klopp C, Quillet E, Boudinot P
Lien Pubmed
Résumé
The viral hemorrhagic septicemia virus (VHSV) is a major threat for salmonid farming and for wild fish populations worldwide. Previous studies have highlighted the importance of innate factors regulated by a major quantitative trait locus (QTL) for the natural resistance to waterborne VHSV infection in rainbow trout. The aim of this study was to analyze the early transcriptomic response to VHSV inoculation in cell lines derived from previously described resistant and susceptible homozygous isogenic lines of rainbow trout to obtain insights into the molecular mechanisms responsible for the resistance to the viral infection.
Mots clés
Antiviral resistance, QTL, Rainbow trout, Transcriptome deep sequencing, VHSV
Référence
BMC Genomics. 2018 Jun 19;19(1):482