Laboratory identification of cryoglobulinemia from automated blood cell counts, fresh blood samples, and blood films.
Fiche publication
Date publication
avril 2002
Journal
American journal of clinical pathology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr LESESVE Jean-François
Tous les auteurs :
Fohlen-Walter A, Jacob C, Lecompte T, Lesesve JF
Lien Pubmed
Résumé
Four cases showing different means to detect cryoglobulins are reported: effects on blood cell counts performed on 2 technologically different automated hematology instruments and microscopic features in fresh blood samples and on May-Grünwald-Giemsa-stained bloodfilms. These cases were chosen for their instructive value in depicting all artifacts associated with cryoglobulins. Laboratory recognition of the cryoglobulins is important to correct factitious results with automated blood cell counters, mainly pseudoleukocytosis and pseudothrombocytosis. Moreover cryoglobulin-induced laboratory artifacts may be the first factor prompting the assessment for cryoglobulinemia and the diagnosis of the underlying cause.
Mots clés
Autoanalysis, Blood Cell Count, Cryoglobulinemia, blood, Erythrocyte Count, Humans, Leukocyte Count, Lymphoma, B-Cell, complications, Multiple Myeloma, complications, Platelet Count
Référence
Am. J. Clin. Pathol.. 2002 Apr;117(4):606-14