An Endogenous Mammalian Retinoid X Receptor Ligand, At Last!
Fiche publication
Date publication
mai 2016
Journal
ChemMedChem
Auteurs
Membres identifiés du Cancéropôle Est :
Dr KREZEL Wojciech
Tous les auteurs :
de Lera ÁR, Krezel W, Rühl R
Lien Pubmed
Résumé
9-cis-Retinoic acid was identified and claimed to be the endogenous ligand of the retinoid X receptors (RXRs) in 1992. Since then, the endogenous presence of this compound has never been rigorously confirmed. Instead, concerns have been raised by other groups that have reported that 9-cis-retinoic acid is undetectable or that its presence occurs at very low levels. Furthermore, these low levels could not satisfactorily explain the physiological activation of RXR. Alternative ligands, among them various lipids, have also been identified, but also did not fulfill criteria for rigorous endogenous relevance, and their consideration as bona fide endogenous mammalian RXR ligand has likewise been questioned. Recently, novel studies claim that the saturated analogue 9-cis-13,14-dihydroretinoic acid functions as an endogenous physiologically relevant mammalian RXR ligand.
Mots clés
dihydroretinoids, endogenous ligands, receptors, retinoids, vitamins
Référence
ChemMedChem. 2016 05 19;11(10):1027-37