[Obesity and asthma: Mechanisms and therapeutic options].
Fiche publication
Date publication
décembre 2019
Journal
Revue des maladies respiratoires
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DORMOY Valerian
Tous les auteurs :
Guguen C, Launois C, Dormoy V, Dewolf M, Dumazet A, Dury S, Lebargy F, Deslee G, Perotin JM
Lien Pubmed
Résumé
Asthma and obesity are both common conditions, which lead to a substantial public health burden. The obese-asthma phenotype is characterized by poor asthma control, impaired lung function and decreased efficacy of inhaled treatment. However, this phenotype is highly heterogeneous and involves numerous mechanisms, including systemic inflammation and adipokines. A role for microbiota modifications and genetics has been suggested. Obese-asthma patient management currently consists in weight loss and usual anti-asthmatic treatment. New therapeutic options are being evaluated.
Mots clés
Adipokines, Asthma, Asthme, Microbiota, Microbiote, Obesity, Obésité, Phenotype
Référence
Rev Mal Respir. 2019 Dec 18;: