Poly-epsilon-caprolactone tungsten oxide nanoparticles as a contrast agent for X-ray computed tomography.
Fiche publication
Date publication
mars 2014
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MELY Yves
Tous les auteurs :
Jakhmola A, Anton N, Anton H, Messaddeq N, Hallouard F, Klymchenko A, Mely Y, Vandamme TF
Lien Pubmed
Résumé
Inorganic nanomaterials based on heavy elements represent a new class of contrast agents for X-ray computed tomography (CT). Recent advances have shown that these materials are highly suited for CT imaging due to their high density and X-ray absorption capabilities. In this contribution, we demonstrated that tungsten oxide (WO3) nanoparticles coated by poly-epsilon-caprolactone (PCL) can be used as efficient contrast agent for CT imaging. The obtained particles were characterized by electron microscopy (TEM and SEM), and dynamic light scattering (DLS). We also validated their use for enhanced in vivo imaging, since these nanoparticles were observed to display high X-ray attenuation properties and circulation time (up to 3 h), permitting blood pool imaging.
Référence
Biomaterials. 2014 Mar;35(9):2981-6