Increased anxiety and synaptic plasticity in estrogen receptor beta -deficient mice.
Fiche publication
Date publication
octobre 2001
Journal
Proceedings of the National Academy of Sciences of the United States of America
Auteurs
Membres identifiés du Cancéropôle Est :
Pr CHAMBON Pierre, Dr KREZEL Wojciech
Tous les auteurs :
Krezel W, Dupont S, Krust A, Chambon P, Chapman PF
Lien Pubmed
Résumé
Estrogens are powerful modulators of neuronal physiology and in humans may affect a broad range of functions, including reproductive, emotional, and cognitive behaviors. We studied the contribution of estrogen receptors (ERs) in modulation of emotional processes and analyzed the effects of deleting ERalpha or ERbeta in mice. Behavior consistent with increased anxiety was observed principally in ERbeta mutant females and was associated with a reduced threshold for the induction of synaptic plasticity in the basolateral amygdala. Local increase of 5-hydroxytryptamine 1a receptor expression in medial amygdala may contribute to these changes. Our data show that, particularly in females, there is an important role for ERbeta-mediated estrogen signaling in the processing of emotional behavior.
Mots clés
Amygdala, physiology, Animals, Anxiety, metabolism, Behavior, Animal, Electrophysiology, Estrogen Receptor alpha, Estrogen Receptor beta, Female, Male, Maze Learning, Mice, Mice, Inbred C57BL, Mice, Knockout, Neuronal Plasticity, physiology, Receptors, Estrogen, genetics, Serotonin, metabolism, Signal Transduction, physiology, Synaptic Transmission, physiology, gamma-Aminobutyric Acid, metabolism
Référence
Proc. Natl. Acad. Sci. U.S.A.. 2001 Oct;98(21):12278-82