The sonic hedgehog signaling pathway is reactivated in human renal cell carcinoma and plays orchestral role in tumor growth.
Fiche publication
Date publication
décembre 2009
Journal
Molecular cancer
Auteurs
Membres identifiés du Cancéropôle Est :
Pr JACQMIN Didier, Pr LANG Hervé, Dr LINDNER Véronique, Dr MASSFELDER Thierry, Dr DORMOY Valerian
Tous les auteurs :
Dormoy V, Danilin S, Lindner V, Thomas L, Rothhut S, Coquard C, Helwig JJ, Jacqmin D, Lang H, Massfelder T
Lien Pubmed
Résumé
Human clear cell renal cell carcinoma (CRCC) remains resistant to therapies. Recent advances in Hypoxia Inducible Factors (HIF) molecular network led to targeted therapies, but unfortunately with only limited clinical significance. Elucidating the molecular processes involved in kidney tumorigenesis and resistance is central to the development of improved therapies, not only for kidney cancer but for many, if not all, cancer types. The oncogenic PI3K/Akt, NF-kB and MAPK pathways are critical for tumorigenesis. The sonic hedgehog (SHH) signaling pathway is crucial to normal development.
Mots clés
Animals, Apoptosis, Blotting, Western, Carcinoma, Renal Cell, metabolism, Cell Division, Cell Line, Tumor, Cell Proliferation, Hedgehog Proteins, metabolism, Humans, Kidney Neoplasms, metabolism, Mice, Mice, Nude, Reverse Transcriptase Polymerase Chain Reaction, Signal Transduction, Veratrum Alkaloids, pharmacology, Von Hippel-Lindau Tumor Suppressor Protein, metabolism
Référence
Mol. Cancer. 2009 Dec;8:123