Hypogonadotropic hypogonadism in men with hereditary hemochromatosis.
Fiche publication
Date publication
janvier 2017
Journal
Basic and clinical andrology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr KOSCINSKI Isabelle, Pr HUBERT Jacques
Tous les auteurs :
El Osta R, Grandpre N, Monnin N, Hubert J, Koscinski I
Lien Pubmed
Résumé
Hereditary hemochromatosis is a genetic disease that progresses silently. This disease is often diagnosed late when complications appear. Hypogonadotropic hypogonadism (HH) is one of the classical complications of hemochromatosis. Its frequency is declining probably because of earlier diagnosis and better informed physicians. Certain symptoms linked to HH can have an impact on a patient's sexuality, such as decreased libido, erectile dysfunction, and impairment of ejaculation, as well as on his reproductive capacities. This review is based on an online search in English, French and German language publications found in PubMed/Medline, up to 23 September 2016 using the following key word: Male infertility, Hypogonadotropic Hypogonadism, Hereditary Hemochromatosis. Thirty-four papers met these inclusion criteria. This review describes the impact of iron overload on male fertility, resulting in hypogonadotropic hypogonadism and proposes treatment modalities.
Mots clés
Hereditary Hemochromatosis, Hypogonadotropic Hypogonadism, Male infertility
Référence
Basic Clin Androl. 2017 ;27:13