Stereoselective Four-Component Synthesis of Functionalized 2,3-Dihydro-4-Nitropyrroles.
Fiche publication
Date publication
janvier 2019
Journal
Frontiers in chemistry
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DESAUBRY Laurent
Tous les auteurs :
Wang D, Ma X, Dong L, Feng H, Yu P, Désaubry L
Lien Pubmed
Résumé
We report a metal-free and stereoselective four-component reaction between α-ketoamides, amines, aromatic aldehydes and β-nitroalkenes or β-pivaloxy-nitroalkanes to obtain 2,3-dihydro-4-nitropyrroles functionalized in every position. The heterocycles accessible using this reaction may have utility in the synthesis of pharmacologically active compounds.
Mots clés
1, 5-dipolar cyclization, cascade reaction, dihydropyrroles, heterocycles, ketoamide, multicomponent reaction, nitro
Référence
Front Chem. 2019 ;7:810