Homocitrulline: a new marker for differentiating acute from chronic renal failure.
Fiche publication
Date publication
janvier 2016
Journal
Clinical chemistry and laboratory medicine
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GILLERY Philippe
Tous les auteurs :
Desmons A, Jaisson S, Pietrement C, Rieu P, Wynckel A, Gillery P
Lien Pubmed
Résumé
Carbamylation is a non-enzymatic post-translational modification of proteins characterized by the addition of isocyanic acid to amino groups. As isocyanic acid mainly originates from the spontaneous dissociation of urea, carbamylation rate is increased during renal failure. The aim of the study was to evaluate serum homocitrulline (HCit), which results from the carbamylation of ε-amino groups of lysine (Lys) residues, in acute renal failure (ARF) and to determine if it could be useful for differentiating acute from chronic renal failure (CRF).
Mots clés
Acute Kidney Injury, blood, Aged, Biomarkers, blood, Citrulline, analogs & derivatives, Female, Humans, Kidney Failure, Chronic, blood, Male, Middle Aged
Référence
Clin. Chem. Lab. Med.. 2016 Jan;54(1):73-9