Galectin-3 Blockade Reduces Renal Fibrosis in Two Normotensive Experimental Models of Renal Damage.
Fiche publication
Date publication
janvier 2016
Journal
PloS one
Auteurs
Membres identifiés du Cancéropôle Est :
Pr ROSSIGNOL Patrick
Tous les auteurs :
Martinez-Martinez E, Ibarrola J, Calvier L, Fernandez-Celis A, Leroy C, Cachofeiro V, Rossignol P, Lopez-Andres N
Lien Pubmed
Résumé
Galectin-3 (Gal-3), a β-galactoside-binding lectin, is increased in kidney injury and its pharmacological blockade reduces renal damage in acute kidney injury, hyperaldosteronism or hypertensive nephropathy. We herein investigated the effects of pharmacological Gal-3 inhibition by modified citrus pectin (MCP) in early renal damage associated with obesity and aortic stenosis (AS).
Mots clés
Acute Kidney Injury, pathology, Animals, Aortic Valve Stenosis, complications, Diet, High-Fat, adverse effects, Disease Models, Animal, Fibrosis, Galectin 3, antagonists & inhibitors, Kidney, pathology, Male, Obesity, complications, Pectins, pharmacology, Rats, Rats, Wistar, Real-Time Polymerase Chain Reaction
Référence
PLoS ONE. 2016 ;11(11):e0166272