Flavaglines Ameliorate Experimental Colitis and Protect Against Intestinal Epithelial Cell Apoptosis and Mitochondrial Dysfunction.
Fiche publication
Date publication
janvier 2016
Journal
Inflammatory bowel diseases
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DESAUBRY Laurent
Tous les auteurs :
Han J, Zhao Q, Basmadjian C, Désaubry L, Theiss AL
Lien Pubmed
Résumé
Flavaglines are a family of natural compounds shown to have anti-inflammatory and cytoprotective effects in neurons and cardiomyocytes. Flavaglines target prohibitins as ligands, which are scaffold proteins that regulate mitochondrial function, cell survival, and transcription. This study tested the therapeutic potential of flavaglines to promote intestinal epithelial cell homeostasis and to protect against a model of experimental colitis in which inflammation is driven by epithelial ulceration.
Mots clés
Animals, Apoptosis, drug effects, Benzofurans, pharmacology, Biological Products, pharmacology, Caco-2 Cells, Colitis, chemically induced, Cytokines, metabolism, Dextran Sulfate, toxicity, Epithelial Cells, drug effects, Female, Humans, Inflammation Mediators, metabolism, Intestinal Mucosa, drug effects, Intestines, drug effects, Male, Mice, Mice, Inbred C57BL, Mitochondria, drug effects, Reactive Oxygen Species, metabolism
Référence
Inflamm. Bowel Dis.. 2016 Jan;22(1):55-67