Characterization of endogenous Claudin1 expression, motility and susceptibility to Hepatitis C Virus in CRISPR knock-in cells.
Fiche publication
Date publication
février 2020
Journal
Biology of the cell
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BAUMERT Thomas, Pr MELY Yves, Dr RONDE Philippe
Tous les auteurs :
Clément CMH, Deffieu MS, Dorobantu CM, Baumert TF, Ayala-Nunez NV, Mély Y, Ronde P, Gaudin R
Lien Pubmed
Résumé
Claudin1 (CLDN1) is a four-span transmembrane protein localized at cell-cell tight junctions (TJs), playing an important role in epithelial impermeability and tissue homeostasis under physiological conditions. Moreover, CLDN1 expression is upregulated in several cancers, and the level of CLDN1 expression has been proposed as a prognostic marker of patient survival.
Mots clés
CLDN1, Claudin, FRAP, Gene editing, HCV, Hepatocellular carcinoma, Permeability
Référence
Biol. Cell. 2020 Feb 7;: