Aza- and Azo-Stilbenes: Bio-Isosteric Analogs of Resveratrol.
Fiche publication
Date publication
janvier 2020
Journal
Molecules (Basel, Switzerland)
Auteurs
Membres identifiés du Cancéropôle Est :
Dr LIZARD Gérard
Tous les auteurs :
Lizard G, Latruffe N, Vervandier-Fasseur D
Lien Pubmed
Résumé
Several series of natural polyphenols are described for their biological and therapeutic potential. Natural stilbenoid polyphenols, such as trans-resveratrol, pterostilbene and piceatannol are well-known for their numerous biological activities. However, their moderate bio-availabilities, especially for trans-resveratrol, prompted numerous research groups to investigate innovative and relevant synthetic resveratrol derivatives. This review is focused on isosteric resveratrol analogs aza-stilbenes and azo-stilbenes in which the C=C bond between both aromatic rings was replaced with C=N or N=N bonds, respectively. In each series, synthetic ways will be displayed, and structural sights will be highlighted and compared with those of resveratrol. The biological activities of some of these molecules will be presented as well as their potential therapeutic applications. In some cases, structure-activity relationships will be discussed.
Mots clés
aza-stilbene, azo-stilbene, bio-isosterism, structure-activity relationship, trans-resveratrol
Référence
Molecules. 2020 Jan 30;25(3):