A Novel Analog Reasoning Paradigm: New Insights in Intellectually Disabled Patients.
Fiche publication
Date publication
janvier 2016
Journal
PloS one
Auteurs
Membres identifiés du Cancéropôle Est :
Pr CHELLY Jamel
Tous les auteurs :
Curie A, Brun A, Cheylus A, Reboul A, Nazir T, Bussy G, Delange K, Paulignan Y, Mercier S, David A, Marignier S, Merle L, de Fréminville B, Prieur F, Till M, Mortemousque I, Toutain A, Bieth E, Touraine R, Sanlaville D, Chelly J, Kong J, Ott D, Kassai B, Hadjikhani N, Gollub RL, des Portes V
Lien Pubmed
Résumé
Intellectual Disability (ID) is characterized by deficits in intellectual functions such as reasoning, problem-solving, planning, abstract thinking, judgment, and learning. As new avenues are emerging for treatment of genetically determined ID (such as Down's syndrome or Fragile X syndrome), it is necessary to identify objective reliable and sensitive outcome measures for use in clinical trials.
Mots clés
Adolescent, Adult, Case-Control Studies, Cognition, Down Syndrome, physiopathology, Female, Fragile X Syndrome, physiopathology, Homeodomain Proteins, genetics, Humans, Intellectual Disability, genetics, Male, Middle Aged, Mutation, Thinking, Transcription Factors, genetics, Young Adult
Référence
PLoS ONE. 2016 ;11(2):e0149717