Prefolded Synthetic G-Quartets Display Enhanced Bioinspired Properties.
Fiche publication
Date publication
janvier 2016
Journal
Chemistry (Weinheim an der Bergstrasse, Germany)
Auteurs
Membres identifiés du Cancéropôle Est :
Dr MONCHAUD David
Tous les auteurs :
Flack T, Constantin T, Penasse S, Dejeu J, Gennaro B, Jourdan M, Laguerre A, Pirrotta M, Monchaud D, Spinelli N, Defrancq E
Lien Pubmed
Résumé
A water-soluble template-assembled synthetic G-quartet (TASQ) based on the use of a macrocyclodecapeptide scaffold was designed to display stable intramolecular folds alone in solution. The preformation of the guanine quartet, demonstrated by NMR and CD investigations, results in enhanced peroxidase-type biocatalytic activities and improved quadruplex-interacting properties. Comparison of its DNAzyme-boosting properties with the ones of previously published TASQ revealed that, nowadays, it is the best DNAzyme-boosting agent.
Mots clés
Biocatalysis, DNA, Catalytic, chemistry, G-Quadruplexes, Models, Molecular, Nucleic Acid Conformation, Solutions, chemistry, Water, chemistry
Référence
Chemistry. 2016 Jan 26;22(5):1760-7