Relationship between cardiorespiratory phase coherence during hypoxia and genetic polymorphism in humans.
Fiche publication
Date publication
janvier 2020
Journal
The Journal of physiology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr POUSSEL Mathias
Tous les auteurs :
Lancaster G, Debevec T, Millet GP, Poussel M, Willis SJ, Mramor M, Goričar K, Osredkar D, Dolžan V, Stefanovska A
Lien Pubmed
Résumé
High altitude-induced hypoxia in humans evokes a pattern of breathing known as periodic breathing (PB), where the regular oscillations corresponding to rhythmic expiration and inspiration are modulated by slow-periodic oscillations. The phase coherence between instantaneous heart rate (IHR) and respiration is shown to increase significantly at the frequency of periodic breathing during acute and sustained normobaric and hypobaric hypoxia. It is also shown that polymorphism in specific genes, NOTCH4 and CAT, is significantly correlated with this coherence, and thus with the incidence of PB. Differences in phase shifts between blood flow signals and respiratory and PB oscillations clearly demonstrate contrasting origins of the mechanisms underlying normal respiration and PB. These novel findings provide better understanding of both the genetic and physiological mechanisms responsible for respiratory control during hypoxia at altitude, by linking genetic factors with cardiovascular dynamics, as evaluated by phase coherence.
Mots clés
CAT, NOTCH4, cardiovascular dynamics, heart rate variability, hypoxia, periodic breathing, wavelet analysis
Référence
J. Physiol. (Lond.). 2020 Jan 20;: