[Autophagy in T and B cell homeostasis: recycling for sustainable growth].
Fiche publication
Date publication
mars 2016
Journal
Medecine sciences : M/S
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MULLER Sylviane, Dr GROS Frédéric
Tous les auteurs :
Arnold J, Murera D, Arbogast F, Muller S, Gros F
Lien Pubmed
Résumé
Macroautophagy often abbreviated by "autophagy" is an intracellular degradation mechanism linked to lysosomal activity. Autophagy is conserved from yeast to mammals and plays a role in the response to energetic stress and in organelle homeostasis. Autophagy is also involved in the regulation of immunity, in particular in the adaptive immune response, which involves B and T lymphocytes. It was indeed shown that autophagy impacts the development of B and T cells as well as the education of T cells in the thymus. Autophagy also modulates activation, survival and polarization of T cells. It plays a role in antigen presentation by B cells, and in their TLR-mediated activation, and thus likely in their initial activation. Finally, autophagy is required for the survival of memory lymphocytes and effector cells like antibody-producing plasma cells. Interestingly, autophagy is deregulated in several autoimmune pathologies. The modulation of this phenomenon could possibly lead to new treatments aiming at limiting lymphocyte activation driving these pathologies.
Mots clés
Animals, Autophagy, physiology, B-Lymphocytes, physiology, Homeostasis, immunology, Humans, Immunity, Innate, physiology, T-Lymphocytes, physiology
Référence
Med Sci (Paris). 2016 Mar;32(3):281-9