Trichodysplasia spinulosa: a polyomavirus infection specifically targeting follicular keratinocytes in immunocompromised patients.
Fiche publication
Date publication
mars 2016
Journal
The British journal of dermatology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr AUBIN François
Tous les auteurs :
Rouanet J, Aubin F, Gaboriaud P, Berthon P, Feltkamp MC, Bessenay L, Touzé A, Nicol JT, Franck F, D'Incan M
Lien Pubmed
Résumé
Trichodysplasia spinulosa (TS) is a rare skin disease, caused by a specific polyomavirus, occurring in immunocompromised patients. The pathophysiological mechanisms of TS are not yet fully understood. By using polymerase chain reaction and skin biopsy immunostaining we report evidence, in a paediatric case, of follicular keratinocytes being the primary target of trichodysplasia spinulosa-associated polyomavirus.
Mots clés
Child, Hair Diseases, pathology, Hair Follicle, pathology, Humans, Immunocompromised Host, Immunosuppressive Agents, adverse effects, Keratinocytes, virology, Male, Opportunistic Infections, complications, Polyomavirus Infections, complications, Skin Diseases, Viral, complications
Référence
Br. J. Dermatol.. 2016 Mar;174(3):629-32