Persistent polyclonal binucleated B-cell lymphocytosis and MECOM gene amplification.
Fiche publication
Date publication
mars 2016
Journal
BMC research notes
Auteurs
Membres identifiés du Cancéropôle Est :
Dr LESESVE Jean-François
Tous les auteurs :
Cornet E, Mossafa H, Courel K, Lesesve JF, Troussard X
Lien Pubmed
Résumé
Persistent Polyclonal Binucleated B-cell Lymphocytosis (PPBL) is characterized by a chronic polyclonal B-cell lymphocytosis with binucleated lymphocytes and a polyclonal increase in serum immunoglobulin-M. Cytogenetic is characterized by the presence of a supernumerary isochromosome +i(3)(q10), premature chromosome condensation and chromosomal instability. Outcome of PPBL patients is mostly benign, but subsequent malignancies could occur. The aim of our study is to provide an update of clinical and cytogenetic characteristics of our large cohort of PPBL patients, to describe subsequent malignancies occurring during the follow-up, and to investigate the role of the long arm of chromosome 3 in PPBL.
Mots clés
Adult, Aged, Antigens, CD19, genetics, B-Lymphocytes, immunology, Chromosomal Instability, Chromosome Aberrations, Chromosomes, Human, Pair 3, DNA-Binding Proteins, genetics, Female, Follow-Up Studies, Hematologic Neoplasms, etiology, Humans, Immunoglobulin M, blood, In Situ Hybridization, Fluorescence, Karyotyping, Lymphocytosis, complications, Male, Middle Aged, Oligonucleotide Array Sequence Analysis, Polymorphism, Single Nucleotide, Proto-Oncogenes, genetics, Transcription Factors, genetics
Référence
BMC Res Notes. 2016 Mar;9:138