RF-amide neuropeptides and their receptors in Mammals: Pharmacological properties, drug development and main physiological functions.
Fiche publication
Date publication
avril 2016
Journal
Pharmacology & therapeutics
Auteurs
Membres identifiés du Cancéropôle Est :
Dr SIMONIN Frédéric
Tous les auteurs :
Quillet R, Ayachi S, Bihel F, Elhabazi K, Ilien B, Simonin F
Lien Pubmed
Résumé
RF-amide neuropeptides, with their typical Arg-Phe-NH2 signature at their carboxyl C-termini, belong to a lineage of peptides that spans almost the entire life tree. Throughout evolution, RF-amide peptides and their receptors preserved fundamental roles in reproduction and feeding, both in Vertebrates and Invertebrates. The scope of this review is to summarize the current knowledge on the RF-amide systems in Mammals from historical aspects to therapeutic opportunities. Taking advantage of the most recent findings in the field, special focus will be given on molecular and pharmacological properties of RF-amide peptides and their receptors as well as on their implication in the control of different physiological functions including feeding, reproduction and pain. Recent progress on the development of drugs that target RF-amide receptors will also be addressed.
Mots clés
Amides, metabolism, Animals, Drug Discovery, methods, Humans, Mammals, metabolism, Neuropeptides, metabolism, Receptors, Neuropeptide, metabolism
Référence
Pharmacol. Ther.. 2016 Apr;160:84-132