Prognostic value of antibodies to Merkel cell polyomavirus T antigens and VP1 protein in patients with Merkel cell carcinoma.
Fiche publication
Date publication
avril 2016
Journal
The British journal of dermatology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr AUBIN François
Tous les auteurs :
Samimi M, Molet L, Fleury M, Laude H, Carlotti A, Gardair C, Baudin M, Gouguet L, Maubec E, Avenel-Audran M, Esteve E, Wierzbicka-Hainaut E, Beneton N, Aubin F, Rozenberg F, Dupin N, Avril MF, Lorette G, Guyetant S, Coursaget P, Touzé A
Lien Pubmed
Résumé
Merkel cell polyomavirus (MCPyV) is the main aetiological agent of Merkel cell carcinoma (MCC). Serum antibodies against the major MCPyV capsid protein (VP1) are detected in the general population, whereas antibodies against MCPyV oncoproteins (T antigens) have been reported specifically in patients with MCC.
Mots clés
Adult, Aged, Aged, 80 and over, Antigens, Viral, Tumor, blood, Biomarkers, Tumor, blood, Capsid Proteins, blood, Carcinoma, Merkel Cell, immunology, Enzyme-Linked Immunosorbent Assay, Female, Humans, Kaplan-Meier Estimate, Male, Merkel cell polyomavirus, immunology, Middle Aged, Neoplasm Recurrence, Local, immunology, Polyomavirus Infections, immunology, Prognosis, Risk Assessment, methods, Skin Neoplasms, immunology, Tumor Virus Infections, immunology
Référence
Br. J. Dermatol.. 2016 Apr;174(4):813-22