Interferon-inducible MX2 is a host restriction factor of hepatitis B virus replication.
Fiche publication
Date publication
décembre 2019
Journal
Journal of hepatology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BAUMERT Thomas
Tous les auteurs :
Wang YX, Niklasch M, Liu T, Wang Y, Shi B, Yuan W, Baumert TF, Yuan Z, Tong S, Nassal M, Wen YM
Lien Pubmed
Résumé
Noncytolytic curing of hepatitis B virus (HBV) infected hepatocytes by cytokines including type I interferons (IFNs) is of importance for resolving acute and chronic infection. However, as IFNs stimulate hundreds of genes those most relevant for HBV suppression remain largely unknown. Amongst them are the large Mx GTPases. Human MX1 (or MxA) is active against many RNA viruses while MX2 (or MxB) was recently found to restrict human immunodeficiency virus 1, hepatitis C virus, and herpesviruses. Here we investigated the anti-HBV activity of MX2.
Mots clés
antiviral mechanism, covalently closed circular DNA, hepatitis B virus, infection, interferon, interferon stimulated gene, replication, transcription
Référence
J. Hepatol.. 2019 Dec 18;: