Heavy smoking and lung cancer: are women at higher risk? Result of the ICARE study.
Fiche publication
Date publication
mars 2014
Auteurs
Membres identifiés du Cancéropôle Est :
Dr WORONOFF Anne-Sophie
Tous les auteurs :
Papadopoulos A, Guida F, Leffondre K, Cenee S, Cyr D, Schmaus A, Radoi L, Paget-Bailly S, Carton M, Menvielle G, Woronoff AS, Tretarre B, Luce D, Stucker I
Lien Pubmed
Résumé
BACKGROUND: Whether women are more or equally susceptible to the carcinogenic effects of cigarette smoke on the lungs compared with men is a matter of controversy. Using a large French population-based case-control study, we compared the lung cancer risk associated with cigarette smoking by gender. METHODS: The study included 2276 male and 650 female cases and 2780 male and 775 female controls. Lifetime smoking exposure was represented by the comprehensive smoking index (CSI), which combines the duration, intensity and time since cessation of smoking habits. The analysis was conducted among the ever smokers. All of the models were adjusted for age, department (a regional administrative unit), education and occupational exposures. RESULTS: Overall, we found that the lung cancer risk was similar among men and women. However, we found that women had a two-fold greater risk associated with a one-unit increase in CSI than men of developing either small cell carcinoma (OR=15.9, 95% confidence interval (95% CI) 7.6, 33.3 and 6.6, 95% CI 5.1, 8.5, respectively; P
Référence
Br J Cancer. 2014 Mar 4;110(5):1385-91