Evaluation of invasive aspergillosis risk for immunocompromised patients alternatively hospitalized in hematology intensive care unit and at home.
Fiche publication
Date publication
mars 2014
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BERCEANU Ana, Pr DECONINCK Eric, Dr LAROSA Fabrice
Tous les auteurs :
Rocchi S, Reboux G, Larosa F, Scherer E, Daguindau E, Berceanu A, Deconinck E, Millon L, Bellanger AP
Lien Pubmed
Résumé
Contrary to hospital exposure, little is known about the indoor fungal exposure of hematology patients at home. The aim of our study was to investigate the mold exposure of hematology patients both at home and at hospital to assess their invasive aspergillosis (IA) risk. Fungal exposure was assessed by quantifying opportunistic molds at hospital during hospitalization and in homes of 53 hematology patients. IA was diagnosed in 13/53 patients and invasive fungal infection (IFI) in one patient. In hospital, no opportunistic species, or low levels of opportunistic species were found in 98% of weekly controls. Only 2% of hematology intensive care unit (ICU) controls showed a high level of A. fumigatus spores in corridor air. Five IA patients were hospitalized during these periods. Seven dwellings out of 53 (5/14 dwellings of IA/IFI patients and 2/39 dwellings of non-IA patients) had a percentage of A. fumigatus and A. flavus to total mold (significant predictor variable of IA/IFI in our study, general linear model, p-value = 0.02) as high as 15%. Maintaining a "zero Aspergillus" goal at hospital is essential, and establishing specific and individually opportunistic mold monitoring at home could help to further reduce the IA risk through continuous surveillance. This article is protected by copyright. All rights reserved.
Référence
Indoor Air. 2014 Mar 13