Combined use of multiparametric flow cytometry and cytomorphology to enhance detection of neuroblastoma metastatic cells in bone marrow.
Fiche publication
Date publication
décembre 2019
Journal
International journal of laboratory hematology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr CHASTAGNER Pascal, Dr LESESVE Jean-François, Pr BROSEUS Julien, Dr DREUMONT Natacha
Tous les auteurs :
Manenq C, Lesesve JF, Dreumont N, Massin F, Salignac S, Mansuy L, Chastagner P, Latger-Cannard V, Broséus J
Lien Pubmed
Résumé
In the context of neuroblastoma (NB), the screening for bone marrow (BM) metastasis is a recurrent issue for hematology laboratory routine practice. Detection of low tumor burden using light microscopy is often difficult. In this regard, our objective was to evaluate the performance of multiparametric flow cytometry (FC) for detecting NB metastatic cells in BM.
Mots clés
bone marrow, flow cytometry, metastasis, neuroblastoma, surface markers
Référence
Int J Lab Hematol. 2019 Dec 10;: