Reconstruction of gene regulatory networks reveals chromatin remodelers and key transcription factors in tumorigenesis.
Fiche publication
Date publication
mai 2016
Journal
Genome medicine
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GRONEMEYER Hinrich, Dr MENDOZA Manuel
Tous les auteurs :
Malysheva V, Mendoza-Parra MA, Saleem MA, Gronemeyer H
Lien Pubmed
Résumé
Alterations in genetic and epigenetic landscapes are known to contribute to the development of different types of cancer. However, the mechanistic links between transcription factors and the epigenome which coordinate the deregulation of gene networks during cell transformation are largely unknown.
Mots clés
Cell Line, Cell Transformation, Neoplastic, genetics, Chromatin Assembly and Disassembly, Gene Expression Profiling, methods, Gene Expression Regulation, Neoplastic, Gene Regulatory Networks, Humans, Sequence Analysis, RNA, methods, Transcription Factors, genetics
Référence
Genome Med. 2016 05;8(1):57