Hypoxic Environment and Paired Hierarchical 3D and 2D Models of Pediatric -Mutated Gliomas Recreate the Patient Tumor Complexity.
Fiche publication
Date publication
novembre 2019
Journal
Cancers
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DONTENWILL Monique, Pr ENTZ-WERLE Natacha, Dr GUENOT Dominique, Dr GUERIN Eric, Pr NAMER Izzie-Jacques, Dr VILLA Pascal, Dr LHERMITTE Benoît, Dr REITA Damien
Tous les auteurs :
Blandin AF, Durand A, Litzler M, Tripp A, Guérin É, Ruhland E, Obrecht A, Keime C, Fuchs Q, Reita D, Lhermitte B, Coca A, Jones C, Rebel IL, Villa P, Namer IJ, Dontenwill M, Guenot D, Entz-Werle N
Lien Pubmed
Résumé
Pediatric high-grade gliomas (pHGGs) are facing a very dismal prognosis and representative pre-clinical models are needed for new treatment strategies. Here, we examined the relevance of collecting functional, genomic, and metabolomics data to validate patient-derived models in a hypoxic microenvironment.
Mots clés
hypoxia, intra-tumor heterogeneity, models, pediatric high-grade glioma, tumor and cell metabolism
Référence
Cancers (Basel). 2019 Nov 26;11(12):