Heritability of a resting heart rate in a 20-year follow-up family cohort with GWAS data: Insights from the STANISLAS cohort.
Fiche publication
Date publication
décembre 2019
Journal
European journal of preventive cardiology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr ROSSIGNOL Patrick
Tous les auteurs :
Xhaard C, Dandine-Roulland C, Villemereuil P, Floch EL, Bacq-Daian D, Machu JL, Ferreira JP, Deleuze JF, Zannad F, Rossignol P, Girerd N
Lien Pubmed
Résumé
The association between resting heart rate (HR) and cardiovascular outcomes, especially heart failure, is now well established. However, whether HR is mainly an integrated marker of risk associated with other features, or rather a genetic origin risk marker, is still a matter for debate. Previous studies reported a heritability ranging from 14% to 65%.
Mots clés
Heart rate, cardiovascular diseases, family study, genetic relatedness matrix, heritability
Référence
Eur J Prev Cardiol. 2019 Dec 2;:2047487319890763