Follicular T helper cells shape the HCV-specific CD4 T cell repertoire after viral elimination.
Fiche publication
Date publication
novembre 2019
Journal
The Journal of clinical investigation
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BAUMERT Thomas
Tous les auteurs :
Smits M, Zoldan K, Ishaque N, Gu Z, Jechow K, Wieland D, Conrad C, Eils R, Fauvelle C, Baumert TF, Emmerich F, Bengsch B, Neumann-Haefelin C, Hofmann M, Thimme R, Boettler T
Lien Pubmed
Résumé
Chronic HCV-infection is characterized by a severe impairment of HCV-specific CD4 T cell help that is driven by chronic antigen stimulation. We aimed to study the fate of HCV-specific CD4 T cells after viral elimination.
Mots clés
Adaptive immunity, Cellular immune response, Immunology, Infectious disease, MHC class 2
Référence
J. Clin. Invest.. 2019 Nov 7;: