Gut microbiome in chronic rheumatic and inflammatory bowel diseases: Similarities and differences.
Fiche publication
Date publication
octobre 2019
Journal
United European gastroenterology journal
Auteurs
Membres identifiés du Cancéropôle Est :
Pr JOUZEAU Jean-Yves, Pr PEYRIN-BIROULET Laurent
Tous les auteurs :
Salem F, Kindt N, Marchesi JR, Netter P, Lopez A, Kokten T, Danese S, Jouzeau JY, Peyrin-Biroulet L, Moulin D
Lien Pubmed
Résumé
Inflammatory bowel diseases (IBDs) and chronic rheumatic diseases (CRDs) are systemic chronic disorders sharing common genetic, immune and environmental factors. About half of patients with IBD develop rheumatic ailments and microscopic intestinal inflammation is present in up to half of CRD patients. IBD and CRD patients also share a common therapeutic armamentarium. Disequilibrium in the complex realm of microbes (known as dysbiosis) that closely interact with the gut mucosal immune system has been associated with both IBD and CRD (spondyloarthritis and rheumatoid arthritis). Whether dysbiosis represents an epiphenomenon or a prodromal feature remains to be determined.
Mots clés
Inflammatory bowel disease, chronic rheumatic diseases, gut microbiota, immunity, inflammation
Référence
United European Gastroenterol J. 2019 Oct;7(8):1008-1032