Visualising the membrane viscosity of porcine eye lens cells using molecular rotors.
Fiche publication
Date publication
mai 2017
Journal
Chemical science
Auteurs
Membres identifiés du Cancéropôle Est :
Dr KLYMCHENKO Andrey
Tous les auteurs :
Sherin PS, López-Duarte I, Dent MR, Kubánková M, Vyšniauskas A, Bull JA, Reshetnikova ES, Klymchenko AS, Tsentalovich YP, Kuimova MK
Lien Pubmed
Résumé
The plasma membranes of cells within the eye lens play an important role in metabolite transport within the avascular tissue of the lens, maintaining its transparency over the entire lifespan of an individual. Here we use viscosity-sensitive 'molecular rotors' to map the microscopic viscosity within these unusual cell membranes, establishing that they are characterised by an unprecedentedly high degree of lipid organisation.
Référence
Chem Sci. 2017 May 1;8(5):3523-3528