Recent Advances in Fluorescent Probes for Lipid Droplets.
Fiche publication
Date publication
septembre 2018
Journal
Materials (Basel, Switzerland)
Auteurs
Membres identifiés du Cancéropôle Est :
Dr KLYMCHENKO Andrey
Tous les auteurs :
Fam TK, Klymchenko AS, Collot M
Lien Pubmed
Résumé
Lipid droplets (LDs) are organelles that serve as the storage of intracellular neutral lipids. LDs regulate many physiological processes. They recently attracted attention after extensive studies showed their involvement in metabolic disorders and diseases such as obesity, diabetes, and cancer. Therefore, it is of the highest importance to have reliable imaging tools. In this review, we focus on recent advances in the development of selective fluorescent probes for LDs. Their photophysical properties are described, and their advantages and drawbacks in fluorescence imaging are discussed. At last, we review the reported applications using these probes including two-photon excitation, in vivo and tissue imaging, as well as LDs tracking.
Mots clés
bioimaging, fluorescent probes, lipid droplets
Référence
Materials (Basel). 2018 Sep 18;11(9):