Evidence that hydrogen peroxide, a component of oxidative stress, induces high-anxiety-related behaviour in mice.
Fiche publication
Date publication
février 2019
Journal
Behavioural brain research
Auteurs
Membres identifiés du Cancéropôle Est :
Pr SOULIMANI Rachid
Tous les auteurs :
Bouayed J, Soulimani R
Lien Pubmed
Résumé
The link between oxidative stress and high-anxiety-related behaviour is uncontested; but the cause-effect relationship has yet to be completely elucidated. Here, the behavioural effects of hydrogen peroxide (HO), given to mice (n = 10 per group) in drinking water at 1%, were assessed in the light/dark choice test, the open field, the elevated-plus maze and the hole-board test. Compared to controls (drinking only water), subacute exposure (10-15 days) of mice to HO, the major component of reactive oxygen species (ROS) and the precursor of potent oxidants (hydroxyl radical and hypochlorous acid), affected emotional responses by inducing an anxious behaviour associated with hyperactivity. Our findings clearly showed that HO-treated mice exhibited anxiogenic behaviour in the light/dark choice test and in the hole-board test. Moreover, HO-treated mice displayed a hyperactive behaviour, revealed by a significant increase in the number of crossings made in the open field test relative to controls. Although HO-exposed mice made significantly less head-dippings in the open arms than controls, HO-induced hyperactivity may have blurred anxiogenic-like behaviour in HO-treated mice in the elevated-plus maze. Our findings provide the evidence that HO, an oxidizing component, caused high-anxiety-related behaviour associated with hyperactivity in mice. Antioxidants may play a role in preventing or attenuating oxidative stress-related anxiety.
Mots clés
Anxiety, Hydrogen peroxide (H(2)O(2)), Hyperactivity, Oxidative stress, Reactive oxygen species (ROS)
Référence
Behav. Brain Res.. 2019 02 1;359:292-297