A fluorogenic BODIPY molecular rotor as an apoptosis marker.
Fiche publication
Date publication
juin 2019
Journal
Chemical communications (Cambridge, England)
Auteurs
Membres identifiés du Cancéropôle Est :
Dr KLYMCHENKO Andrey
Tous les auteurs :
Ashokkumar P, Ashoka AH, Collot M, Das A, Klymchenko AS
Lien Pubmed
Résumé
Based on a BODIPY molecular rotor and a zinc-dipicolylamine receptor, we designed a fluorogenic probe for the detection of apoptosis. Being poorly emissive in solution and with healthy cells, it selectively binds phosphatidylserine of early apoptotic cells and internalizes into late apoptotic cells, lighting up its green fluorescence.
Mots clés
Apoptosis, Biomarkers, Tumor, analysis, Boron Compounds, chemistry, Cell Line, Cell Membrane, metabolism, Fluorescent Dyes, chemistry, HeLa Cells, Humans, Organometallic Compounds, analysis, Phosphatidylserines, chemistry, Picolinic Acids, analysis
Référence
Chem. Commun. (Camb.). 2019 Jun 11;55(48):6902-6905