Constitutive or Induced HIF-2 Addiction is Involved in Resistance to Anti-EGFR Treatment and Radiation Therapy in HNSCC.
Fiche publication
Date publication
octobre 2019
Journal
Cancers
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GAIDDON Christian, Dr JUNG Alain, Dr PENCREACH Erwan, Dr COLIAT Pierre
Tous les auteurs :
Coliat P, Ramolu L, Jégu J, Gaiddon C, Jung AC, Pencreach E
Lien Pubmed
Résumé
management of head and neck squamous cell carcinomas (HNSCC) include anti-Epidermal Growth Factor Receptor (EGFR) antibodies and radiotherapy, but resistance emerges in most patients. mutations lead to primary resistance to EGFR blockade in metastatic colorectal cancer but are infrequent in HNSCC, suggesting that other mechanisms are implicated. Since hypoxia and Hypoxia Inducible Factor-1 (HIF-1) have been associated with treatment failure and tumor progression, we hypothesized that EGFR/mammalian Target Of Rapamycin (mTOR)/HIF-1 axis inhibition could radiosensitize HNSCC.
Mots clés
HIF-2α, anti-EGFR targeted therapy, head and neck squamous cell carcinoma, oncogenic addiction, resistance
Référence
Cancers (Basel). 2019 Oct 21;11(10):