[The role of chemotherapy in the treatment of non-metastatic, non-small cell bronchial cancers].
Fiche publication
Date publication
décembre 2001
Journal
Revue medicale de Bruxelles
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MASCAUX Céline
Tous les auteurs :
Sculier JP, Berghmans T, Paesmans M, Branle F, Lemaitre F, Mascaux C, Meert AP, Steels E, Vallot F, Lafitte JJ
Lien Pubmed
Résumé
A systematic review of the literature about the role of chemotherapy in comparison to local therapies--surgery or radiotherapy--in non-small cells lung cancers has identified 35 randomised trials. The methodological assessment has not shown significant difference for quality scores between negative or positive studies in term of survival effect. The aggregation (meta-analysis) shows a significant effect of survival improvement by chemotherapy, whatever all indications are considered or subgroups like adjuvant chemotherapy to surgery, neoadjuvant chemotherapy, concomitant radio-chemotherapy and induction chemotherapy prior to thoracic irradiation.
Mots clés
Belgium, epidemiology, Carcinoma, Bronchogenic, drug therapy, Carcinoma, Non-Small-Cell Lung, drug therapy, Combined Modality Therapy, Humans, Lung Neoplasms, drug therapy, Neoadjuvant Therapy, methods, Neoplasm Staging, Pneumonectomy, standards, Radiotherapy, Adjuvant, standards, Research Design, standards, Survival Analysis, Treatment Outcome
Référence
Rev Med Brux. 2001 Dec;22(6):477-87