EGFR and KRAS Mutations Predict the Incidence and Outcome of Brain Metastases in Non-Small Cell Lung Cancer.
Fiche publication
Date publication
décembre 2016
Journal
International journal of molecular sciences
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MASCAUX Céline
Tous les auteurs :
Tomasini P, Serdjebi C, Khobta N, Metellus P, Ouafik L, Nanni I, Greillier L, Loundou A, Fina F, Mascaux C, Barlesi F
Lien Pubmed
Résumé
Lung cancer is the leading cause of brain metastases (BM). The identification of driver oncogenes and matched targeted therapies has improved outcome in non-small cell lung cancer (NSCLC) patients; however, a better understanding of BM molecular biology is needed to further drive the process in this field.
Mots clés
EGFR, KRAS, brain metastasis, incidence, lung neoplasm, recurrence, survival
Référence
Int J Mol Sci. 2016 Dec 18;17(12):