Genomic Testing in Lung Cancer: Past, Present, and Future.

Fiche publication


Date publication

mars 2018

Journal

Journal of the National Comprehensive Cancer Network : JNCCN

Auteurs

Membres identifiés du Cancéropôle Est :
Pr MASCAUX Céline


Tous les auteurs :
Mascaux C, Tsao MS, Hirsch FR

Résumé

Precision medicine commonly refers to the selection of the most effective cancer treatments based on the presence of specific biomarkers (eg, genomic abnormalities) in a patient's tumor. Therefore, genomic testing is used to identify patients whose tumors harbor the vulnerability that is sensitive to corresponding targeted therapies. This approach allows for the selection of patients who have the greatest chance of deriving benefit from the treatments, reduces toxicity, and significantly improves outcome; precision medicine is recommended for advanced non-small cell lung cancer. This article reviews the evolution of genomic testing in lung cancer, from its development, including first success and failures, to its current use in the care of patients with lung cancer, and addresses future considerations, such as the expected increase of targetable abnormalities, the need to follow the genomic profile over time, and tumor heterogeneity.

Mots clés

Biomarkers, Tumor, Genetic Testing, methods, Genomics, methods, Humans, Lung Neoplasms, diagnosis, Molecular Targeted Therapy, Mutation, Neoplasm Staging, Prognosis

Référence

J Natl Compr Canc Netw. 2018 03;16(3):323-334