Regulation of LRP-1 expression: make the point.
Fiche publication
Date publication
avril 2014
Auteurs
Membres identifiés du Cancéropôle Est :
Pr DEDIEU Stéphane, Dr BENNASROUNE Amar
Tous les auteurs :
Emonard H, Theret L, Bennasroune AH, Dedieu S
Lien Pubmed
Résumé
The low-density lipoprotein receptor-related protein-1 (LRP-1) is a membrane receptor displaying both scavenging and signaling functions. The wide variety of extracellular ligands and of cytoplasmic scaffolding and signaling proteins interacting with LRP-1 gives it a major role not only in physiological processes, such as embryogenesis and development, but also in critical pathological situations, including cancer and neurological disorders. In this review, we describe the molecular mechanisms involved at distinct levels in the regulation of LRP-1, from its expression to the proper location and stability at the cell surface.
Référence
Pathol Biol (Paris). 2014 Apr;62(2):84-90