Diagnostic performance of stress myocardial perfusion imaging performed with a new semiconductor camera and a very low dose protocol.
Fiche publication
Date publication
avril 2014
Auteurs
Membres identifiés du Cancéropôle Est :
Pr KARCHER Gilles
Tous les auteurs :
Perrin M, Djaballah W, Moulin F, Imbert L, Poussier S, Besseau C, Verger A, Karcher G, Marie PY
Lien Pubmed
Résumé
Introduction. This retrospective study aimed to assess the performances in the detection of coronary artery disease patients of the stress myocardial perfusion imaging (MPI) performed with a semiconductor camera, a very low dose stress-rest protocol and short recording times. Material and methods. We analyzed consecutive MPI exams, which has been routinely planed with the "D-SPECT" semiconductor camera, a 1day stress-rest protocol, very low doses of Sestamibi-Tc-99m (120 MBq at stress and 360 MBq at rest for a 75 kg body weight patient) and short acquisition-times targeting the recording of 500 myocardial kcounts (on average, 8 min for stress and 3 min for rest). The ability to detect coronary artery stenosis (> 50% diameter reduction) was assessed in a group of 118 patients, who had coronary angiography at = 1 coronary artery stenosis were 85%, 83% and 78%, respectively; and normalcy rate was 96%. Mean effective doses were: (1) 4.9 +/- 1.4 mSv in the group with coronary angiography and where most exams (90%) comprised both stress and rest MPI; and (2) 1.9 +/- 1.5 mSv in the low probability group and where most exams (70%) comprised only stress MPI. Conclusion. When performed with a sensitive semiconductor camera and a very low dose stress-rest protocol, MPI provides high diagnostic performances, equivalent to those documented with conventional cameras in the same study setting, but with dramatic reduction of patients' radiation. (C) 2014 Elsevier Masson SAS. All rights reserved.
Référence
Med Nucl-imag Fonct Metab. 2014 Apr;38(2):111-21.