Toxicity and efficacy of cetuximab associated with several modalities of IMRT for locally advanced head and neck cancer.
Fiche publication
Date publication
juillet 2016
Journal
Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique
Auteurs
Membres identifiés du Cancéropôle Est :
Pr NOEL Georges
Tous les auteurs :
Bibault JE, Morelle M, Perrier L, Pommier P, Boisselier P, Coche-Dequéant B, Gallocher O, Alfonsi M, Bardet É, Rives M, Calugaru V, Chajon E, Noël G, Mecellem H, Pérol D, Dussart S, Giraud P
Lien Pubmed
Résumé
Intensity-modulated radiation therapy (IMRT) has shown its interest for head and neck cancer treatment. In parallel, cetuximab has demonstrated its superiority against exclusive radiotherapy. The objective of this study was to assess the acute toxicity, local control and overall survival of cetuximab associated with different IMRT modalities compared to platinum-based chemotherapy and IMRT in the ARTORL study (NCT02024035).
Mots clés
Antineoplastic Agents, therapeutic use, Carcinoma, Squamous Cell, mortality, Cetuximab, therapeutic use, Chemotherapy, Adjuvant, Drug Eruptions, etiology, Female, Head and Neck Neoplasms, mortality, Humans, Male, Middle Aged, Mucositis, etiology, Neoplasm Recurrence, Local, Propensity Score, Prospective Studies, Radiotherapy, Intensity-Modulated
Référence
Cancer Radiother. 2016 Jul;20(5):357-61