Platinum(iv) N-heterocyclic carbene complexes: their synthesis, characterisation and cytotoxic activity.
Fiche publication
Date publication
juillet 2016
Journal
Dalton transactions (Cambridge, England : 2003)
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BELLEMIN-LAPONNAZ Stéphane, Pr FOURNEL Sylvie
Tous les auteurs :
Bouché M, Dahm G, Wantz M, Fournel S, Achard T, Bellemin-Laponnaz S
Lien Pubmed
Résumé
Platinum(ii) N-heterocyclic carbene complexes have been oxidized by bromine or iodobenzene dichloride to provide the fully characterised corresponding platinum(iv) NHC complexes. Antiproliferative activities of Pt(iv) NHC complexes were assayed against several cancer cell lines and the results were correlated with respect to their stability. Mechanistic investigations revealed that mitochondrial dysfunction and ROS production were associated with the cytotoxic process induced by these compounds.
Référence
Dalton Trans. 2016 Jul;45(28):11362-8