LEON-BIS: multiple alignment evaluation of sequence neighbours using a Bayesian inference system.
Fiche publication
Date publication
juillet 2016
Journal
BMC bioinformatics
Auteurs
Membres identifiés du Cancéropôle Est :
Dr POCH Olivier, Dr THOMPSON Julie
Tous les auteurs :
Vanhoutreve R, Kress A, Legrand B, Gass H, Poch O, Thompson JD
Lien Pubmed
Résumé
A standard procedure in many areas of bioinformatics is to use a multiple sequence alignment (MSA) as the basis for various types of homology-based inference. Applications include 3D structure modelling, protein functional annotation, prediction of molecular interactions, etc. These applications, however sophisticated, are generally highly sensitive to the alignment used, and neglecting non-homologous or uncertain regions in the alignment can lead to significant bias in the subsequent inferences.
Référence
BMC Bioinformatics. 2016 Jul;17(1):271