Expression of the semicarbazide-sensitive amine oxidase in articular cartilage: its role in terminal differentiation of chondrocytes in rat and human.
Fiche publication
Date publication
juillet 2016
Journal
Osteoarthritis and cartilage
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GILLET Pierre, Pr MAGDALOU Jacques, Pr MAINARD Didier
Tous les auteurs :
Filip A, Pinzano A, Bianchi A, Fève B, Jalkanen S, Gillet P, Mainard D, Lacolley P, Magdalou J, Mercier N
Lien Pubmed
Résumé
Semicarbazide-sensitive amine oxidase (SSAO) catalyzes the oxidation of primary amines into ammonia and reactive species (hydrogen peroxide, aldehydes). It is highly expressed in mammalian tissues, especially in vascular smooth muscle cells and adipocytes, where it plays a role in cell differentiation and glucose transport. The study aims at characterizing the expression and the activity of SSAO in rat and human articular cartilage of the knee, and to investigate its potential role in chondrocyte terminal differentiation.
Référence
Osteoarthr. Cartil.. 2016 Jul;24(7):1223-34