Buffering deleterious polymorphisms in highly constrained parts of HIV-1 envelope by flexible regions.
Fiche publication
Date publication
juillet 2016
Journal
Retrovirology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr NEGRONI Matteo
Tous les auteurs :
Gasser R, Hamoudi M, Pellicciotta M, Zhou Z, Visdeloup C, Colin P, Braibant M, Lagane B, Negroni M
Lien Pubmed
Résumé
Covariation is an essential process that leads to coevolution of parts of proteins and genomes. In organisms subject to strong selective pressure, coevolution is central to keep the balance between the opposite requirements of antigenic variation and retention of functionality. Being the viral component most exposed to the external environment, the HIV-1 glycoprotein gp120 constitutes the main target of the immune response. Accordingly its more external portions are characterised by extensive sequence heterogeneity fostering constant antigenic variation.
Mots clés
Antigenic variation, Coevolution, Envelope, HIV, Viral entry
Référence
Retrovirology. 2016 07 30;13(1):50