Palladium-Catalyzed Chemoselective and Biocompatible Functionalization of Cysteine-Containing Molecules at Room Temperature.
Fiche publication
Date publication
août 2016
Journal
Chemistry (Weinheim an der Bergstrasse, Germany)
Auteurs
Membres identifiés du Cancéropôle Est :
Dr CIANFERANI Sarah, Dr WAGNER Alain, Dr KOLODYCH Sergii, Dr KONIEV Sasha
Tous les auteurs :
Al-Shuaeeb RA, Kolodych S, Koniev O, Delacroix S, Erb S, Nicolaÿ S, Cintrat JC, Brion JD, Cianférani S, Alami M, Wagner A, Messaoudi S
Lien Pubmed
Résumé
The third generation of aminobiphenyl palladacycle pre-catalyst "G3-Xantphos" enables functionalization of peptides containing cysteine in high yields. The conjugation (bioconjugation) occurs chemoselectively at room temperature under biocompatible conditions. Extension of the method to protein functionalization allows selective bioconjugation of the trastuzumab antibody.
Référence
Chemistry. 2016 Aug;22(32):11365-70