The remarkable UV light invulnerability of thymine GNA dinucleotides.
Fiche publication
Date publication
octobre 2019
Journal
Chemical communications (Cambridge, England)
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GUILLAUME Dominique
Tous les auteurs :
Coantic-Castex S, Martinez A, Harakat D, Guillaume D, Clivio P
Lien Pubmed
Résumé
We herein demonstrate the UV resistance of glycol nucleic acid (GNA) dinucleotides. This resistance sustains the hypothesis of GNA as a nucleic acid prebiotic ancestor on early Earth, a time of intense solar UV light. Such photorobustness, due to the absence of intrastrand base stacking, could offer an opportunity for nanodevice development requiring challenging UV conditions.
Référence
Chem. Commun. (Camb.). 2019 Oct 2;: